Infectious Disease Panels - IntenCiv Diagnostics

IntenCiv — Infectious Disease Panels | Clinical Intelligence

Clinical Intelligence

What are Infectious Disease Panels?

IDP represents a paradigm shift from sequential single-pathogen testing toward simultaneous, syndromic molecular profiling — designed for the pace of critical care.

Syndromic Architecture

Instead of testing one organism at a time, IDP evaluates multiple clinically relevant pathogens simultaneously — grouped by the syndrome, not the microbe.

Speed Over Culture

PCR-based multiplex detection delivers actionable results in hours, not days. Faster than culture, broader than routine serology, and more sensitive than antigen tests.

ICU & OPD Ready

Designed for high-acuity environments where empiric therapy must be refined quickly. Enables de-escalation of broad-spectrum antibiotics and reduces unnecessary antimicrobial exposure.

Antimicrobial Stewardship

Precise pathogen identification supports targeted therapy — reducing collateral damage of broad-spectrum agents and curtailing resistance selection pressure.

Conventional Testing vs. IDP

Old Method

Single pathogen per test

→

IDP

30–40 pathogens, one run

TAT

48–72 hours (culture)

→

TAT

4–6 hours (PCR)

Sensitivity

Culture: 50–70%

→

Sensitivity

PCR: >95% for most targets

Empiric Therapy

Broad, prolonged

→

Empiric Therapy

Targeted, de-escalated

MDR Detection

Delayed or missed

→

MDR Detection

Resistance genes detected

Panel Classification

Select a Panel to Explore

Five major syndromic categories, each with tiered panels ranging from focused detection to comprehensive profiling. Tap any card to review organisms, clinical use, and ordering guidance.

Viral Respiratory

Fever + cough, ICU ventilated patient, influenza-like illness, RSV in immunocompromised

6 sub-panels · Influenza A/B/C, RSV, COVID, HMPV, Adenovirus +

Bacterial Respiratory

CAP / HAP workup, atypical pneumonia, persistent lower respiratory tract infection

2 sub-panels · Bordetella, Legionella, Klebsiella, Mycoplasma +

Fungal Respiratory

Immunocompromised patients, prolonged ICU stay, cavitary lung lesions, suspected PCP

1 panel · Aspergillus, Mucorales, PCP

Comprehensive Respiratory

Severe CAP/HAP, intubated patients, immunocompromised with complex respiratory illness

2 panels · 20–30+ organisms bacterial + viral combined

Encephalitis / CNS

Acute neurological decline, fever + altered consciousness, CSF pleocytosis, suspected viral meningitis

5 panels · Neuro-9, Neuro-11, Neuro-13, Encephalitis, Bacterial CNS

Sepsis Panels

ICU patients with SIRS/sepsis criteria, fever + hemodynamic instability, fungaemia workup, MDR organism surveillance

2 panels · Fungal + Bacterial (MRSA, VRE, Carbapenem resistance)

Tropical Fever

Undifferentiated acute fever, thrombocytopenia, travel history, monsoon season presentations

3 panels · 4 / 6 / 8 pathogens including Dengue, Malaria, Scrub Typhus, Leptospirosis

STI / Genital

Urethral/vaginal discharge, pelvic inflammatory disease, genital ulcer, cervicitis workup, HPV screening

3 panels · HPV high-risk, Viral STI, Bacterial-Protozoal

Panel Details

Panel Name

Sample: —

Clinical Use Case

Why This Panel Matters

Parameters Covered

Smart Decision Support

Clinical Presentation → Panel

Rapid pattern-matching for OPD and ICU settings. Match the presentation to the appropriate panel with confidence.

Respiratory

Fever + productive cough + hypoxia in ICU patient on ventilator

Comprehensive Respiratory Panel

Respiratory

Influenza-like illness + suspected COVID/RSV co-infection

Flu & Covid Panel / Respiratory Viral Panel 3

CNS / Encephalitis

Fever + altered sensorium + CSF pleocytosis — viral etiology suspected

Neuro-9 or Neuro-viro 11

CNS / Encephalitis

Acute meningitis + bacterial etiology suspected (age >60 or immunocompromised)

Bacterial Encephalitis Panel

Sepsis

ICU patient + SIRS + prolonged broad-spectrum antibiotics — fungaemia concern

Fungal Sepsis Panel

Sepsis

ICU patient with clinical deterioration + MDR organism history or risk factors

Bacterial Sepsis Panel (MRSA/VRE/Carbapenem)

Tropical Fever

Fever + thrombocytopenia — dengue / malaria / chikungunya presentation

Fever 4-Pathogen Panel

Tropical Fever

Undifferentiated fever + hepatosplenomegaly + jaundice — leptospirosis / scrub typhus

Fever 6-Pathogen or 8-Pathogen Panel

STI / Urogenital

Cervicitis / PID workup or urethral discharge with negative culture

Bacterial-Protozoal STI Panel

STI / Urogenital

Cervical screening + high-risk HPV genotyping required

HPV-16/18 High-Risk Detection Panel

Technology Platform

Molecular Diagnostics Infrastructure

IDP panels are built on multiplexed real-time PCR — the diagnostic gold standard for simultaneous pathogen detection with superior analytical performance.

Multiplexed Real-Time PCR

Simultaneous amplification and detection of 10–40 pathogen targets within a single reaction. Fluorescent probe chemistry enables precise quantitative detection without post-amplification processing.

Syndromic Panel Architecture

Primers and probes selected for clinically co-presenting pathogens within each syndrome. Panel design reflects real-world differential diagnoses, not alphabetical pathogen lists.

Internal Controls & Quality Assurance

Each run includes extraction controls and internal amplification controls to validate specimen adequacy. Ensures no false-negatives due to inhibitors or inadequate sampling.

Resistance Gene Detection

Select sepsis panels include molecular markers for MRSA (3 markers), VRE (3 markers), and carbapenem resistance (5 markers) — enabling direct antibiogram inference in critical care.

Performance vs. Conventional Methods

Clinical Sensitivity PCR: ~95%

Blood Culture Sensitivity ~50–70%

Turnaround: IDP PCR 4–6 hrs

Turnaround: Culture 48–72 hrs

Pathogen Breadth: IDP Up to 40 targets

Pathogen Breadth: Routine Test 1–2 targets

Sample Compatibility

NP/OP Swab in VTMBAL / SputumCSFWhole BloodEDTA PlasmaSerumUrineCervical Swab in VTM

Clinical Advantages

Why IDP Changes the Standard of Care

Every hour of diagnostic uncertainty in the ICU carries measurable clinical consequences. IDP compresses that window to its minimum.

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Faster Diagnosis

PCR-based results in 4–6 hours versus 48–72 hours for culture. In sepsis management, every hour of optimized therapy improves survival by measurable margins.

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Targeted Therapy

Identifies the causative pathogen early in the disease course, enabling de-escalation from empiric broad-spectrum regimens to precisely targeted agents.

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Antimicrobial Stewardship

Reduces unnecessary antibiotic exposure — curtailing resistance selection pressure, C. diff risk, and organ toxicity from prolonged broad-spectrum therapy.

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MDR Detection

Direct molecular detection of resistance markers (MRSA, VRE, carbapenem resistance genes) — no culture step required for resistance profiling in critical scenarios.

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ICU Decision Support

Designed for high-acuity settings where diagnostic uncertainty directly influences therapeutic escalation, isolation decisions, and organ-support planning.

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Diagnostic Completeness

Co-infections — clinically common but frequently missed — are detected in a single run. Mixed viral-bacterial respiratory illness and polymicrobial sepsis are identified simultaneously.